Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:3:2408.
doi: 10.1038/srep02408.

Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of renal cell carcinoma

Jinsheng Xu  1 , Zhanjun Guo, Junxia Zhang, Liwen Cui, Shenglei Zhang, Yaling Bai
Affiliations

Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of renal cell carcinoma

Jinsheng Xu et al. Sci Rep. 2013.

Abstract

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described in various types of cancers, and their association with cancer risk and disease outcome has been extensively identified. In the present study, we investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-based series of renal cell carcinoma(RCC). The SNP sites of nucleotides 16293A/G were identified for their association with age-at-onset using the log-rank test. The age-at-onset of patients with the minor allele G genotype was significantly lower than that of patients with the A genotype at the 16293 site (p < 0.001). Genetic polymorphisms in the D-loop are predictive markers of age-at-onset in RCC patients. Accordingly, the analysis of genetic polymorphisms in the mitochondrial D-loop may help identify RCC patient subgroups at high risk of early onset.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Comparison of the age-at-onset for RCC patients according to the 16293A/G genotype in the D-loop.
(a),the age-at-onset curve for 75 RCC patients. (b), the age-at-onset curve for 60 RCC patients. RCC, renal cell cancer.
See this image and copyright information in PMC

References

    1. Remon J., Lianes P. & Martinez S. Brain metastases from renal cell carcinoma. Should we change the current standard? Cancer Treat Rev 38, 249–257 (2012). - PubMed
    1. Salehipoor M. et al. Role of viruses in renal cell carcinoma. Saudi J Kidney Dis Transpl 23, 53–57 (2012). - PubMed
    1. Zhao P., Dai M., Chen W. & Li N. Cancer trends in China. Jpn J Clin Oncol 40, 281–285 (2010). - PubMed
    1. Staehler M., Rohrmann K., Haseke N., Stief C. G. & Siebels M. Targeted agents for the treatment of advanced renal cell carcinoma. Curr Drug Targets 6, 835–846 (2005). - PubMed
    1. Guo Z., Yang H., Zhang F., Zhang R. & Wang C. Single nucleotide polymorphisms in the mitochondrial displacement loop and age-at-onset of esophageal squamous cell carcinoma. Oncol Lett 3, 482–484 (2012). - PMC - PubMed

Publication types

MeSH terms