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Meta-Analysis
. 2014 May;63(5):800-7.
doi: 10.1136/gutjnl-2013-305189. Epub 2013 Aug 9.

Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia

Iona Cheng  1 , Jonathan M Kocarnik, Logan Dumitrescu, Noralane M Lindor, Jenny Chang-Claude, Christy L Avery, Christian P Caberto, Shelly-Ann Love, Martha L Slattery, Andrew T Chan, John A Baron, Lucia A Hindorff, Sungshim Lani Park, Fredrick R Schumacher, Michael Hoffmeister, Peter Kraft, Anne M Butler, David J Duggan, Lifang Hou, Chris S Carlson, Kristine R Monroe, Yi Lin, Cara L Carty, Sue Mann, Jing Ma, Edward L Giovannucci, Charles S Fuchs, Polly A Newcomb, Mark A Jenkins, John L Hopper, Robert W Haile, David V Conti, Peter T Campbell, John D Potter, Bette J Caan, Robert E Schoen, Richard B Hayes, Stephen J Chanock, Sonja I Berndt, Sebastien Küry, Stephane Bézieau, Jose Luis Ambite, Gowri Kumaraguruparan, Danielle M Richardson, Robert J Goodloe, Holli H Dilks, Paxton Baker, Brent W Zanke, Mathieu Lemire, Steven Gallinger, Li Hsu, Shuo Jiao, Tabitha A Harrison, Daniela Seminara, Christopher A Haiman, Charles Kooperberg, Lynne R Wilkens, Carolyn M Hutter, Emily White, Dana C Crawford, Gerardo Heiss, Thomas J Hudson, Hermann Brenner, William S Bush, Graham Casey, Loïc Le Marchand, Ulrike Peters
Affiliations
Meta-Analysis

Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia

Iona Cheng et al. Gut. 2014 May.

Abstract

Objective: Genome-wide association studies have identified a large number of single nucleotide polymorphisms (SNPs) associated with a wide array of cancer sites. Several of these variants demonstrate associations with multiple cancers, suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesised that SNPs previously associated with other cancers may additionally be associated with colorectal cancer. In a large-scale study, we examined 171 SNPs previously associated with 18 different cancers for their associations with colorectal cancer.

Design: We examined 13 338 colorectal cancer cases and 40 967 controls from three consortia: Population Architecture using Genomics and Epidemiology (PAGE), Genetic Epidemiology of Colorectal Cancer (GECCO), and the Colon Cancer Family Registry (CCFR). Study-specific logistic regression results, adjusted for age, sex, principal components of genetic ancestry, and/or study specific factors (as relevant) were combined using fixed-effect meta-analyses to evaluate the association between each SNP and colorectal cancer risk. A Bonferroni-corrected p value of 2.92×10(-4) was used to determine statistical significance of the associations.

Results: Two correlated SNPs--rs10090154 and rs4242382--in Region 1 of chromosome 8q24, a prostate cancer susceptibility region, demonstrated statistically significant associations with colorectal cancer risk. The most significant association was observed with rs4242382 (meta-analysis OR=1.12; 95% CI 1.07 to 1.18; p=1.74×10(-5)), which also demonstrated similar associations across racial/ethnic populations and anatomical sub-sites.

Conclusions: This is the first study to clearly demonstrate Region 1 of chromosome 8q24 as a susceptibility locus for colorectal cancer; thus, adding colorectal cancer to the list of cancer sites linked to this particular multicancer risk region at 8q24.

Keywords: COLORECTAL CANCER; EPIDEMIOLOGY; POLYMORPHIC VARIATION.

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Figures

Figure 1
Figure 1. Manhattan plot of the meta-analysis association between risk variants of 18 other cancers and colorectal cancer
The solid line is the Bonferroni-corrected significance threshold. Each association is colored according to the cancer for which the SNP was originally reported, and positioned on the x-axis according to its genomic position.
Figure 2
Figure 2. Forest plot of the association between rs4242382 at Region 1 of chromosome 8q24 and colorectal cancer risk
Study specific and meta-analysis associations are plotted, modeling the A risk allele for prostate cancer.
Figure 3
Figure 3. Forest plot of the association between rs2736100 at the TERT locus at 5p15 and colorectal cancer risk
Study specific and meta-analysis associations are plotted, modeling the G risk allele for glioma.
See this image and copyright information in PMC

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