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. 2013 Jul 7:2013:871308.
doi: 10.1155/2013/871308. Print 2013.

The incidence of colorectal cancer is decreasing in the older age cohorts in the zaanstreek region in the Netherlands: an age-cohort effect

R J L F Loffeld  1 , P E P Dekkers, M Flens
Affiliations

The incidence of colorectal cancer is decreasing in the older age cohorts in the zaanstreek region in the Netherlands: an age-cohort effect

R J L F Loffeld et al. ISRN Gastroenterol. .

Abstract

Introduction. Colorectal cancer (CRC) has a high incidence. Removal of adenomas, the precursor lesion, could be helpful in the prevention of cancer. Aim. To investigate the yearly incidence of CRC in consecutive years. Patients and Methods. All patients diagnosed with CRC in the years 1990 till 2010 were studied. Date of diagnosis, age at time of diagnosis, gender, and localisation of the tumour were assessed. Results. A total of 1575 incident CRC were diagnosed, 865 men (55%) and 710 women (45%). CRC occurred more often in men. In the course of the years, the occurrence of CRC increased. After exclusion of rectal cancer, the percentage of proximal cancer in the colon shows a trend towards increase in the consecutive years. In the twenty consecutive years, the population of the Zaanstreek region increased from 130.000 to 145.330. There was a significant increase of CRC in the age cohort 51-70 in the period of twenty years, while a significant decreasing incidence of cancer was seen in patients above 71 years. Conclusion. The decreasing incidence of colorectal cancer in the age cohorts above 71 years possibly reflects indirect evidence of an age-cohort effect due to removal of adenomas in these age cohorts earlier in life.

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Figures

Figure 1
Figure 1
Presence of colorectal cancer in men and women in the consecutive years.
Figure 2
Figure 2
Number of colorectal cancer in the population and per 100,000 inhabitants.
Figure 3
Figure 3
Proximal and distal cancers in the consecutive years.
Figure 4
Figure 4
Proximal and distal cancer with exclusion of rectal cancer.
Figure 5
Figure 5
Percentage of age cohorts in the population in the period of twenty years.
Figure 6
Figure 6
The absolute numbers of colorectal cancer in three age cohorts.
Figure 7
Figure 7
The percentage of colorectal cancer in the total population in the three age cohorts shown in Figure 6.
Figure 8
Figure 8
Percentage of colorectal cancers in different age cohorts in consecutive years.
Figure 9
Figure 9
Percentage of colorectal cancers in different age cohorts in consecutive years.
Figure 10
Figure 10
Percentage of colorectal cancers in different age cohorts in consecutive years.
Figure 11
Figure 11
Percentage of colorectal cancers in different age cohorts in consecutive years.
See this image and copyright information in PMC

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