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. 2013 Sep 28;49(75):8407-9.
doi: 10.1039/c3cc43838d.

Probing the reactivity of o-phthalaldehydic acid/methyl ester: synthesis of N-isoindolinones and 3-arylaminophthalides

Sreeman K Mamidyala  1 , Matthew A Cooper
Affiliations

Probing the reactivity of o-phthalaldehydic acid/methyl ester: synthesis of N-isoindolinones and 3-arylaminophthalides

Sreeman K Mamidyala et al. Chem Commun (Camb). .

Abstract

A new method for the synthesis of N-substituted isoindolinones and 3-arylaminophthalides was developed through aza-Wittig/cyclisation. The reaction of o-phthalaldehydic acid methyl ester with benzylic, aromatic and aliphatic azides gave N-isoindolinones whereas reaction of o-phthalaldehydic acid with the aromatic azides gave 3-arylaminophthalides.

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