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. 2013 Nov;57(11):5239-46.
doi: 10.1128/AAC.00633-13. Epub 2013 Aug 12.

Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands

Dae Hun Kim  1 , Ji-Young Choi, Hae Won Kim, So Hyun Kim, Doo Ryeon Chung, Kyong Ran Peck, Visanu Thamlikitkul, Thomas Man-Kit So, Rohani M D Yasin, Po-Ren Hsueh, Celia C Carlos, Li Yang Hsu, Latre Buntaran, M K Lalitha, Jae-Hoon Song, Kwan Soo Ko
Affiliations

Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands

Dae Hun Kim et al. Antimicrob Agents Chemother. 2013 Nov.

Abstract

In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaR-type resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenem-resistant A. baumannii in Asia.

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Figures

Fig 1
Fig 1
Structures of resistance islands identified in this study. Eight subtypes of AbaR4-like resistance islands are shown. AbaR4-D36, AbaR4-AB210, Tn6166, and AbaR25 include Tn2006 with a blaOXA-23-like gene. In AbaR4-AB210, Tn6166ΔtniD, AbaR25, and AbaRΔTn2006, a region including tniD and its upstream and downstream sequence was partially deleted.
Fig 2
Fig 2
Structures of resistance islands identified in this study. Three subtypes of AbaR3-like resistance islands are represented. In three isolates, AbaR4-D36 was also found in another region. While the AbaR3-like resistance island of one isolate includes a MARR, a MARR was not found in those of the other four isolates.
Fig 3
Fig 3
Relationships among STs, resistance islands, and locales of isolates used in the analysis of resistance islands. The thickness of the lines is proportional to the number of isolates.
See this image and copyright information in PMC

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