Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2013 Aug 5;8(8):e70436.
doi: 10.1371/journal.pone.0070436. Print 2013.

Effects of wheat and oat-based whole grain foods on serum lipoprotein size and distribution in overweight middle aged people: a randomised controlled trial

Paula Tighe  1 , Garry Duthie, Julie Brittenden, Nicholas Vaughan, William Mutch, William G Simpson, Susan Duthie, Graham W Horgan, Frank Thies
Affiliations
Randomized Controlled Trial

Effects of wheat and oat-based whole grain foods on serum lipoprotein size and distribution in overweight middle aged people: a randomised controlled trial

Paula Tighe et al. PLoS One. .

Abstract

Introduction: Epidemiological studies suggest three daily servings of whole-grain foods (WGF) might lower cardiovascular disease risk, at least partly by lowering serum lipid levels. We have assessed the effects of consuming three daily portions of wholegrain food (provided as wheat or a mixture of wheat and oats) on lipoprotein subclass size and concentration in a dietary randomised controlled trial involving middle aged healthy individuals.

Methods: After a 4-week run-in period on a refined diet, volunteers were randomly allocated to a control (refined diet), wheat, or wheat + oats group for 12 weeks. Our servings were determined in order to significantly increase the intakes of non starch polysaccharides to the UK Dietary Reference Value of 18 g per day in the whole grain groups (18.5 g and 16.8 g per day in the wheat and wheat + oats groups respectively in comparison with 11.3 g per day in the control group). Outcome measures were serum lipoprotein subclasses' size and concentration. Habitual dietary intake was assessed prior and during the intervention. Of the 233 volunteers recruited, 24 withdrew and 3 were excluded.

Results: At baseline, significant associations were found between lipoprotein size and subclasses' concentrations and some markers of cardiovascular risk such as insulin resistance, blood pressure and serum Inter cellular adhesion molecule 1 concentration. Furthermore, alcohol and vitamin C intake were positively associated with an anti-atherogenic lipoprotein profile, with regards to lipoprotein size and subclasses' distribution. However, none of the interventions with whole grain affected lipoprotein size and profile.

Conclusion: Our results indicate that three portions of wholegrain foods, irrelevant of the type (wheat or oat-based) do not reduce cardiovascular risk by beneficially altering the size and distribution of lipoprotein subclasses.

Trial registration: www.Controlled-Trials.com ISRCTN 27657880.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Trial profile.
See this image and copyright information in PMC

References

    1. Jacobs DR, Meyer KA, Hushi LH, Folsom AR (1998) Whole grain intake may reduce the risk of ischaemic heart disease death in postmenopausal women: the Iowa Women's Health Study. Am J Clin Nutr 68: 248–257. - PubMed
    1. Liu S, Stampfer MJ, Hu FB, Giovannucci E, Rimm E, et al. (1999) Whole-grain consumption and risk of CHD: results from the Nurses' Health Study. Am J Clin Nutr 70: 412–419. - PubMed
    1. Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL, et al. (1997) Dietary fiber, glycaemic load, and risk of non-insulin-dependent diabetes mellitus in women. J Am Med Assoc 277: 472–477. - PubMed
    1. Meyer KA, Kushi LH, Jacobs DR Jr, Slavin J, Sellers TA, et al. (2000) Carbohydrates, dietary fiber, and incidence of type 2 diabetes in older women. Am J Clin Nutr 71: 921–930. - PubMed
    1. Anderson JW, Hanna TJ (1999) Impact of non-digestible carbohydrates on serum lipoproteins and risk for cardiovascular disease. J Nutr 129: 1457–1466. - PubMed

Publication types

Associated data