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Review
. 2014 Apr 10;345(2):271-8.
doi: 10.1016/j.canlet.2013.07.031. Epub 2013 Aug 11.

Inflammation and cancer stem cells

Sarah Shigdar  1 , Yong Li  2 , Santanu Bhattacharya  3 , Michael O'Connor  4 , Chunwen Pu  5 , Jia Lin  4 , Tao Wang  4 , Dongxi Xiang  4 , Lingxue Kong  6 , Ming Q Wei  7 , Yimin Zhu  8 , Shufeng Zhou  9 , Wei Duan  10
Affiliations
Review

Inflammation and cancer stem cells

Sarah Shigdar et al. Cancer Lett. .

Abstract

Cancer stem cells are becoming recognised as being responsible for metastasis and treatment resistance. The complex cellular and molecular network that regulates cancer stem cells and the role that inflammation plays in cancer progression are slowly being elucidated. Cytokines, secreted by tumour associated immune cells, activate the necessary pathways required by cancer stem cells to facilitate cancer stem cells progressing through the epithelial-mesenchymal transition and migrating to distant sites. Once in situ, these cancer stem cells can secrete their own attractants, thus providing an environment whereby these cells can continue to propagate the tumour in a secondary niche.

Keywords: Cancer stem cells; Epigenetics; Epithelial–mesenchymal transition; Inflammation; Microenvironment.

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