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Review
. 2013 Sep;4(9):656-63.
doi: 10.1007/s13238-013-3052-7. Epub 2013 Aug 13.

siRNA-mediated DNA methylation and H3K9 dimethylation in plants

Chi Xu  1 , Jing Tian  2 , Beixin Mo  3
Affiliations
Review

siRNA-mediated DNA methylation and H3K9 dimethylation in plants

Chi Xu et al. Protein Cell. 2013 Sep.

Abstract

Heterochromatic siRNAs regulate transcriptional gene silencing by inducing DNA methylation and histone H3K9 dimethylation. Recent advances have revealed the distinct phases involved in siRNA mediated silencing pathway, although the precise functions of a number of factors remain undesignated, putative mechanisms for the connection between DNA and histone methylation have been investigated, and much effort has been invested to understand the biological functions of siRNA-mediated epigenetic modification. In this review, we summarize the mechanism of siRNA-mediated epigenetic modification, which involves the production of siRNA and the recruitments of DNA and histone methytransferases to the target sequences assisted by complementary pairing between 24-nt siRNAs and nascent scaffold RNAs, the roles of siRNA-mediated epigenetic modification in maintaining genome stability and regulating gene expression have been discussed, newly identified players of the siRNA mediated silencing pathway have also been introduced.

Keywords: DNA methylation; argonaute; epigenetic; heterochromatic siRNA; histone methylation.

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References

    1. Alleman M, Sidorenko L, McGinnis K, Seshadri V, Dorweiler JE, White J, Sikkink K, Chandler VL. An RNA-dependent RNA polymerase is required for paramutation in maize. Nature. 2006;442:295–298. doi: 10.1038/nature04884. - DOI - PubMed
    1. Barreto G, Schafer A, Marhold J, Stach D, Swaminathan SK, Handa V, Doderlein G, Maltry N, Wu W, Lyko F, et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature. 2007;445:671–675. doi: 10.1038/nature05515. - DOI - PubMed
    1. Barth TK, Imhof A. Fast signals and slow marks: the dynamics of histone modifications. Trends Biochem Sci. 2010;35:618–626. doi: 10.1016/j.tibs.2010.05.006. - DOI - PubMed
    1. Berger SL. The complex language of chromatin regulation during transcription. Nature. 2007;447:407–412. doi: 10.1038/nature05915. - DOI - PubMed
    1. Bernatavichute YV, Zhang X, Cokus S, Pellegrini M, Jacobsen SE. Genome-wide association of histone H3 lysine nine methylation with CHG DNA methylation in Arabidopsis thaliana. PLoS One. 2008;3:e3156. doi: 10.1371/journal.pone.0003156. - DOI - PMC - PubMed

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