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Comment
. 2013 Aug 27;110(35):14120-1.
doi: 10.1073/pnas.1312901110. Epub 2013 Aug 14.

Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes

Bruce Stillman  1
Affiliations
Comment

Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes

Bruce Stillman. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
A generic eukaryotic cell division cycle showing cyclin A-CDK2 activity and the relative levels of dNTPs. The dNTP-synthesizing enzyme activity of RNR and the relative activity of the dNTP triphosphohydrolase activity of SAMHD1 alternate out of phase with each other. Possibly, cyclin A-CDK2 phosphorylates SAMHD1 and promotes its destruction via ubiquitin-mediated proteolysis, allowing dNTP synthesis by RNR to be coupled to DNA replication during the S phase. This cycle parallels the cycle of assembly of prereplicative complexes (pre-RC) in the G1 phase and its destruction as cells enter into the S phase, a process driven by cyclin A-CDK2.
See this image and copyright information in PMC

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References

    1. Hofer A, Crona M, Logan DT, Sjöberg BM. DNA building blocks: Keeping control of manufacture. Crit Rev Biochem Mol Biol. 2012;47(1):50–63. - PMC - PubMed
    1. Nordlund P, Reichard P. Ribonucleotide reductases. Annu Rev Biochem. 2006;75:681–706. - PubMed
    1. Reichard P, Baldesten A, Rutberg L. Formation of deoxycytidine phosphates from cytidine phosphates in extracts from Escherichia coli. J Biol Chem. 1961;236(4):1150–1157. - PubMed
    1. Elledge SJ, Zhou Z, Allen JB, Navas TA. DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays. 1993;15(5):333–339. - PubMed
    1. Zhao X, Muller EG, Rothstein R. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol Cell. 1998;2(3):329–340. - PubMed

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