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. 2013 Nov;51(11):3499-504.
doi: 10.1128/JCM.01565-13. Epub 2013 Aug 14.

Evaluation of rabies biologics against Irkut virus isolated in China

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Evaluation of rabies biologics against Irkut virus isolated in China

Ye Liu et al. J Clin Microbiol. 2013 Nov.

Abstract

An Irkut virus (IRKV) was recently isolated from a bat in China. The protective ability of rabies biologics available in the Chinese market and experimental biologics against the rabies virus (RABV) and IRKV were assessed in a hamster model via preexposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) experiments. The results demonstrated that a single dose of rabies vaccine did not induce adequate protection against IRKV infection. However, routine PrEP with three doses of vaccine induced complete protection against IRKV infection. Higher doses of RABV immunoglobulins and alpha interferon were required during PEP to protect hamsters against IRKV versus RABV infection. Experimental recombinant vaccines containing IRKV glycoproteins induced more-reliable protection against IRKV than against RABV infection. Those findings may be explained by limited cross-neutralization of these viruses (confirmed via in vitro tests) in conjunction with antigenic distances between RABV and IRKV. These results indicate that the development and evaluation of new biologics for PrEP and PEP are required to ensure sufficient protection against IRKV infection in China and other territories where this virus is present.

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Figures

Fig 1
Fig 1
Comparative amino acid sequence alignment of glycoprotein ectodomains of IRKV and RABV. Numbers, amino acid positions. Boxes, antigenic sites, i.e., site I (aa 226 to 231), site II (aa 34 to 42 and 198 to 200), site III (aa 330 to 338), site IV (aa 251), site G1 (aa 242 to 243), site G5 (aa 261 to 264), and site VI (aa 264) and a novel B-cell epitope (aa 14 to 19). Arrows, four putative N-glycosylation sites.

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