Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Aug 14;19(30):4850-60.
doi: 10.3748/wjg.v19.i30.4850.

New ultrasound techniques for lymph node evaluation

Xin-Wu Cui  1 , Christian Jenssen, Adrian Saftoiu, Andre Ignee, Christoph F Dietrich
Affiliations
Review

New ultrasound techniques for lymph node evaluation

Xin-Wu Cui et al. World J Gastroenterol. .

Abstract

Conventional ultrasound (US) is the recommended imaging method for lymph node (LN) diseases with the advantages of high resolution, real time evaluation and relative low costs. Current indications of transcutaneous ultrasound and endoscopic ultrasound include the detection and characterization of lymph nodes and the guidance for LN biopsy. Recent advances in US technology, such as contrast enhanced ultrasound (CEUS), contrast enhanced endoscopic ultrasound (CE-EUS), and real time elastography show potential to improve the accuracy of US for the differential diagnosis of benign and malignant lymph nodes. In addition, CEUS and CE-EUS have been also used for the guidance of fine needle aspiration and assessment of treatment response. Complementary to size criteria, CEUS could also be used to evaluate response of tumor angiogenesis to anti-angiogenic therapies. In this paper we review current literature regarding evaluation of lymphadenopathy by new and innovative US techniques.

Keywords: Endoscopic ultrasound; Lymph node metastasis; Lymph nodes; Lymphoma; Ultrasound.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Lymph node infiltration, carcinoma. A: With lymph node (LN) specific contrast agents malignant infiltration can be delineated (LKmg) as focal hypoenhancement in the upper part of this perihepatic LN. The lower part (LKnx) shows normal (physiological) enhancement; B: With SonoVue®. Necrotic (non-enhancing, arrows) areas can be detected within this perihepatic lymph node. Necrotic areas are typically for carcinoma infiltration and tuberculosis. IVC: Inferior vena cava; Ao: Aorta; DHC: Common bile duct.
Figure 2
Figure 2
Carcinoma infiltration. Typically vessel destruction with chaotic vessels in the lymph node can be observed. B-mode (A) and 3D angiographic mode (B).
Figure 3
Figure 3
Prostate carcinoma infiltration of the pelvis. Typically vessel destruction with interruption of vessel architecture can be observed in patients with carcinoma. The center of the lymph node is almost non-enhancing except one visible vessel whereas the periphery shows hyperenhancement. Thrombosis of the iliac vein is indicated as well.
Figure 4
Figure 4
Lymph node infiltration (50 mm), non-Hodgkin’s lymphoma. Typically the hilum predominant vessel architecture is preserved (between markers).
Figure 5
Figure 5
Inflammatory perihepatic lymph node dorsal in the hepatoduodenal ligament. Inflammation most often shows no changes of the symmetric lymph node vascularity and homogenous contrast enhancement (A-D). The hilum is indicated. LN: Lymph node.
Figure 6
Figure 6
Colorectal carcinoma with presacral circumscribed lymph node metastasis proven by colonic endoscopic ultrasound using Fine Needle Aspiration Cytology. Sonoelastography reliability test evaluation reveals typically harder (blue) area in the lymph node.
Figure 7
Figure 7
Non-Hodgkin’s lymphoma involving the inguinal region. A: Sonoelastography reliability test evaluation reveals typically asymmetric and circumscribed infiltrated harder (blue) lymph node tissue in low grade follicular cell lymphoma; B: Elastography (acoustic structured quantification) reveals mainly homogenous diffuse infiltration in high grade follicular cell lymphoma.
Figure 8
Figure 8
Endosonography. Enlarged subcarinal lymph nodes in Non Hodgkin Lymphoma (A: B-Mode). Contrast enhanced endoscopic ultrasound demonstrates extensive avascular (necrotic) areas (B) and real time endoscopic indicates hard (blue), infiltrated areas (C), thus targeting endoscopic ultrasound-guided biopsy.
See this image and copyright information in PMC

References

    1. Sharma A, Fidias P, Hayman LA, Loomis SL, Taber KH, Aquino SL. Patterns of lymphadenopathy in thoracic malignancies. Radiographics. 2004;24:419–434. - PubMed
    1. Sumi M, Ohki M, Nakamura T. Comparison of sonography and CT for differentiating benign from malignant cervical lymph nodes in patients with squamous cell carcinoma of the head and neck. AJR Am J Roentgenol. 2001;176:1019–1024. - PubMed
    1. Hocke M, Menges M, Topalidis T, Dietrich CF, Stallmach A. Contrast-enhanced endoscopic ultrasound in discrimination between benign and malignant mediastinal and abdominal lymph nodes. J Cancer Res Clin Oncol. 2008;134:473–480. - PubMed
    1. Prenzel KL, Hölscher AH, Drebber U, Agavonova M, Gutschow CA, Bollschweiler E. Prognostic impact of nodal micrometastasis in early esophageal cancer. Eur J Surg Oncol. 2012;38:314–318. - PubMed
    1. Prenzel KL, Mönig SP, Sinning JM, Baldus SE, Brochhagen HG, Schneider PM, Hölscher AH. Lymph node size and metastatic infiltration in non-small cell lung cancer. Chest. 2003;123:463–467. - PubMed

MeSH terms