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. 2013 Aug 28;135(34):12532-5.
doi: 10.1021/ja405972h. Epub 2013 Aug 15.

Copper-catalyzed carboarylation of alkynes via vinyl cations

Andrew J Walkinshaw  1 , Wenshu Xu, Marcos G Suero, Matthew J Gaunt
Affiliations

Copper-catalyzed carboarylation of alkynes via vinyl cations

Andrew J Walkinshaw et al. J Am Chem Soc. .

Abstract

Copper-catalyzed arylation of electron rich alkynes reveals stabilized trisubstituted vinyl cation equivalents that react with pendant arene nucleophiles to form all carbon tetrasubstituted alkenes. The new process streamlines the synthesis of important medicinally relevant molecules.

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