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Comment
. 2013 Aug 12;24(2):143-4.
doi: 10.1016/j.ccr.2013.07.016.

The origins of tumor-promoting inflammation

Tanya Bondar  1 , Ruslan Medzhitov
Affiliations
Comment

The origins of tumor-promoting inflammation

Tanya Bondar et al. Cancer Cell. .

Abstract

Inflammation is increasingly recognized as an essential component of tumor development, but the origin of tumor-associated inflammation remains largely unknown. In this issue of Cancer Cell, Pribluda and colleagues find that chronic stress initiates senescence-inflammatory response, which can promote tumorigenesis in the absence of exogenous inflammatory triggers.

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  • A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.
    Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y. Pribluda A, et al. Cancer Cell. 2013 Aug 12;24(2):242-56. doi: 10.1016/j.ccr.2013.06.005. Epub 2013 Jul 25. Cancer Cell. 2013. PMID: 23890787

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    1. Pribluda et al., 2013. This issue

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