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Comment
. 2013 Aug 12;24(2):147-9.
doi: 10.1016/j.ccr.2013.07.017.

HSF1 in Translation

Emmanuel de Billy  1 , Paul A Clarke, Paul Workman
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HSF1 in Translation

Emmanuel de Billy et al. Cancer Cell. .
Free article

Abstract

The master regulator of the classical cytoprotective "heat shock" response, heat shock factor 1 (HSF1), is increasingly implicated in cancer pathogenesis, but the mechanisms remain poorly understood. A recent study connects increased protein translation to activation of HSF1 in malignant cells and demonstrates the therapeutic benefit of targeting this link.

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