Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Oct 9;49(78):8755-7.
doi: 10.1039/c3cc45166f.

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Steven H Liang  1 , Thomas Lee Collier, Benjamin H Rotstein, Rebecca Lewis, Mia Steck, Neil Vasdev
Affiliations

Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Steven H Liang et al. Chem Commun (Camb). .

Abstract

We have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[(18)F]fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[(18)F]fluoroaniline were achieved within 3 minutes.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources