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. 2014;38(1):171-84.
doi: 10.3233/JAD-130098.

Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808

David T Chien  1 , A Katrin Szardenings, Shadfar Bahri, Joseph C Walsh, Fanrong Mu, Chunfang Xia, William R Shankle, Alan J Lerner, Min-Ying Su, Arkadij Elizarov, Hartmuth C Kolb
Affiliations
Free article

Early clinical PET imaging results with the novel PHF-tau radioligand [F18]-T808

David T Chien et al. J Alzheimers Dis. 2014.
Free article

Abstract

Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease. We have recently reported early clinical results of a novel PHF-tau targeting PET imaging agent, [F18]-T807. Since then, we have investigated a second novel PHF-tau targeting PET imaging agent, [F18]-T808, with different pharmacokinetic characteristics, which may be favorable for imaging Alzheimer's disease and other tauopathies. Here, we describe the first human brain images with [F18]-T808.

Keywords: Alzheimer's disease; PHF-tau; amyloid-β; brain imaging; mild cognitive impairment; molecular imaging; neurofibrillary tangles; tau; tau aggregates; tauopathy.

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