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. 2013;36(3-4):242-50.
doi: 10.1159/000351671. Epub 2013 Aug 15.

Validation of the Addenbrooke's Cognitive Examination III in frontotemporal dementia and Alzheimer's disease

Sharpley Hsieh  1 , Samantha Schubert, Christopher Hoon, Eneida Mioshi, John R Hodges
Affiliations

Validation of the Addenbrooke's Cognitive Examination III in frontotemporal dementia and Alzheimer's disease

Sharpley Hsieh et al. Dement Geriatr Cogn Disord. 2013.

Abstract

Background/aims: The aims of this study were to validate the newly developed version of the Addenbrooke's Cognitive Examination (ACE-III) against standardised neuropsychological tests and its predecessor (ACE-R) in early dementia.

Methods: A total of 61 patients with dementia (frontotemporal dementia, FTD, n = 33, and Alzheimer's disease, AD, n = 28) and 25 controls were included in the study.

Results: ACE-III cognitive domains correlated significantly with standardised neuropsychological tests used in the assessment of attention, language, verbal memory and visuospatial function. The ACE-III also compared very favourably with its predecessor, the ACE-R, with similar levels of sensitivity and specificity.

Conclusion: The results of this study provide objective validation of the ACE-III as a screening tool for cognitive deficits in FTD and AD.

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