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Review
. 2014 Feb;71(4):615-27.
doi: 10.1007/s00018-013-1445-7. Epub 2013 Aug 15.

Fate choice of post-natal mesoderm progenitors: skeletal versus cardiac muscle plasticity

Domiziana Costamagna  1 , Mattia Quattrocelli, Robin Duelen, Vardine Sahakyan, Ilaria Perini, Giacomo Palazzolo, Maurilio Sampaolesi
Affiliations
Review

Fate choice of post-natal mesoderm progenitors: skeletal versus cardiac muscle plasticity

Domiziana Costamagna et al. Cell Mol Life Sci. 2014 Feb.

Abstract

Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Schematic comparison of factors regulating skeletal and cardiac differentiation, as mentioned in the text. Skeletal fibers and cardiomyocytes are distinguished by αSarcoglycan (Sgca) and nicotinic acetylcholine receptors (nAChRs) in the former, and by Connexin43 (Cx43) and muscarinic acetylcholine receptors (mAChRs) in the latter
Fig. 2
Fig. 2
Schematic representation of resident (within upper colored lobes) and non-resident stem cells for post-natal plasticity in skeletal and cardiac muscles, as reviewed in the text. Within the lower lobe, resident stem cells undergoing lineage switch are reported
See this image and copyright information in PMC

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