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Comment
. 2013 Sep;133(9):2130-3.
doi: 10.1038/jid.2013.261.

Nuclear topology, epigenetics, and keratinocyte differentiation

Michael W Hughes  1 , Wange Lu, Cheng-Ming Chuong
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Free article
Comment

Nuclear topology, epigenetics, and keratinocyte differentiation

Michael W Hughes et al. J Invest Dermatol. 2013 Sep.
Free article

Abstract

Recent progress in epigenetics reveals dynamic chromatin interactions in the nucleus during development, regeneration, reprogramming, and in disease. Higher-order chromatin organization is manifested as changes in the topological distribution of eu-/heterochromatin and in nuclear morphology. We are now able to gain new knowledge about these changes at the genomic level.

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