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Review
. 2013 Dec;9(6):814-32.
doi: 10.1007/s12015-013-9461-4.

The potential of stem cells in the treatment of cardiovascular diseases

Aurora Bernal  1 , Beatriz G Gálvez
Affiliations
Review

The potential of stem cells in the treatment of cardiovascular diseases

Aurora Bernal et al. Stem Cell Rev Rep. 2013 Dec.

Abstract

Although the adult mammalian heart was once believed to be a post-mitotic organ without any capacity for regeneration, recent findings have challenged this dogma. A modified view assigns to the mammalian heart a measurable capacity for regeneration throughout life. The ultimate goals of the cardiac regeneration field have been pursued by multiple strategies, including understanding the developmental biology of cardiomyocytes and cardiac stem and progenitor cells, applying chemical genetics, and engineering biomaterials and delivery methods that facilitate cell transplantation. Successful stimulation of endogenous regenerative capacity in injured adult mammalian hearts can benefit from studies of natural cardiac regeneration.

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Figures

Fig. 1
Fig. 1
Mechanisms to enhance cardiac cell therapy
See this image and copyright information in PMC

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