Bacterial persistence: finding the "sweet spot"
- PMID: 23954150
- DOI: 10.1016/j.chom.2013.07.016
Bacterial persistence: finding the "sweet spot"
Abstract
Studies described by Eisele et al. (2013) and Xavier et al. (2013) in this issue of Cell Host & Microbe show that the bacterial pathogens Salmonella and Brucella exploit the increased levels of glucose present in alternatively activated macrophages to sustain chronic infections in experimentally infected mice.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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PPARγ-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages.Cell Host Microbe. 2013 Aug 14;14(2):159-70. doi: 10.1016/j.chom.2013.07.009. Cell Host Microbe. 2013. PMID: 23954155 Free PMC article.
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Salmonella require the fatty acid regulator PPARδ for the establishment of a metabolic environment essential for long-term persistence.Cell Host Microbe. 2013 Aug 14;14(2):171-182. doi: 10.1016/j.chom.2013.07.010. Cell Host Microbe. 2013. PMID: 23954156 Free PMC article.
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