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. 1990 Sep 6;347(6288):44-9.
doi: 10.1038/347044a0.

Atomic model of the actin filament

K C Holmes  1 , D Popp, W Gebhard, W Kabsch
Affiliations

Atomic model of the actin filament

K C Holmes et al. Nature. .

Abstract

The F-actin filament has been constructed from the atomic structure of the actin monomer to fit the observed X-ray fibre diagram from oriented gels of F-actin. A unique orientation of the monomer with respect to the actin helix has been found. The main interactions are along the two-start helix with a contribution from a loop extending across the filament axis provided by the molecule in the adjacent strand. There are also contacts along the left-handed genetic helix.

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