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. 2013 Sep;140(3):341-7.
doi: 10.1309/AJCP8P2DYNKGRBVI.

Poorly differentiated colorectal cancers: correlation of microsatellite instability with clinicopathologic features and survival

Haitao Xiao  1 , Yong Sik Yoon, Seung-Mo Hong, Seon Ae Roh, Dong-Hyung Cho, Chang Sik Yu, Jin Cheon Kim
Affiliations

Poorly differentiated colorectal cancers: correlation of microsatellite instability with clinicopathologic features and survival

Haitao Xiao et al. Am J Clin Pathol. 2013 Sep.

Abstract

Objectives: To evaluate the association of microsatellite instability (MSI) with clinicopathologic features and oncologic outcomes in patients with poorly differentiated colorectal cancer (PD).

Methods: Study patients were divided into well-differentiated colorectal cancer (WD) and PD, which were compared according to histologic differentiation and MSI status.

Results: Among 1,941 patients, PD was more frequent among microsatellite-unstable tumors (23.6%) than among microsatellite-stable (MSS) tumors (4.2%, P < .001). Patients with PD had worse 4-year overall survival rates than patients with WD (78.6% vs 88.2%, P = 0.010). Compared with MSS-PD tumors, MSI-PD tumors were characterized by right-colon predilection, larger size, and infrequent lymph node metastasis (P < .001 to P = .007).

Conclusions: The clinicopathologic characteristics of PD were closely associated with those of MSI. The outcomes of MSI-PD tumors were better than those of MSS-PD tumors, but this finding did not reach statistical significance.

Keywords: Colorectal adenocarcinoma; Microsatellite instability; Prognosis.

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