Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Apr;16(2):169-71.
doi: 10.4103/0972-2327.112456.

Young girl with abnormal behavior: Anti-N-Methyl-D-Aspartate receptor immune encephalitis

Vinit Suri  1 , Sushma Sharma, Rohan Gupta, Nilesh Jadhao, Kunal Suri
Affiliations
Case Reports

Young girl with abnormal behavior: Anti-N-Methyl-D-Aspartate receptor immune encephalitis

Vinit Suri et al. Ann Indian Acad Neurol. 2013 Apr.

Abstract

Anti N Methyl D Aspartate receptor immune encephalitis (Anti NMDARE) is a recently defined, under-recognized and often misdiagnosed disease, which typically occurs in young females and may be associated with an underlying tumor, usually ovarian teratoma. If diagnosed early, initiation of immunotherapy and tumor removal (if present) may result in recovery. We report a case of a 17 years old girl with Anti NMDARE who was initially misdiagnosed as Functional psychosis, Neuroleptic Malignant Syndrome and Sepsis syndrome. To the best of our knowledge, this is only the second case of anti NMDARE being reported from India. This case report underscores the need for a greater awareness of this entity across multiple specialties, e.g., general medicine, psychiatry and neurology, to ensure a heightened diagnostic suspicion, which can lead to timely diagnosis and adequate therapy of this treatable disease.

Keywords: Immune encephalitis; N-Methyl-D-Aspartate; neuroleptic malignant syndrome; psychosis.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
FLAIR magnetic resonance imaging brain revealing few periventricular (a, arrows) and centrum semiovale (b, arrows) white matter hyper intensities
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Dalmau J, Tüzün E, Wu HY, Masjuan J, Rossi JE, Voloschin A, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007;61:25–36. - PMC - PubMed
    1. Maramattom BV, Philip C, Sundaram PS. Idiopathic anti-NMDA-receptor encephalitis in a young Indian girl. Neurol India. 2010;58:671–2. - PubMed
    1. Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011;10:63–74. - PMC - PubMed
    1. Davies G, Irani SR, Coltart C, Ingle G, Amin Y, Taylor C, et al. Anti-N-methyl-D-aspartate receptor antibodies: A potentially treatable cause of encephalitis in the intensive care unit. Crit Care Med. 2010;38:679–82. - PubMed
    1. Iizuka T, Sakai F, Ide T, Monzen T, Yoshii S, Iigaya M, et al. Anti-NMDA receptor encephalitis in Japan: Long-term outcome without tumor removal. Neurology. 2008;70:504–11. - PMC - PubMed

Publication types