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. 1990 Sep;87(17):6833-7.
doi: 10.1073/pnas.87.17.6833.

Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens

S Szala  1 , Y Kasai, Z Steplewski, U Rodeck, H Koprowski, A J Linnenbach
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Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens

S Szala et al. Proc Natl Acad Sci U S A. 1990 Sep.

Abstract

The human tumor-associated antigen CO-029 is a monoclonal antibody-defined cell surface glycoprotein of 27-34 kDa. By using the high-efficiency COS cell expression system, a full-length cDNA clone for CO-029 was isolated. When transiently expressed in COS cells, the cDNA clone directed the synthesis of an antigen reactive to monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis revealed that CO-029 belongs to a family of cell surface antigens that includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni. CO-029 and ME491 antigen expression and the effect of their corresponding monoclonal antibodies on cell growth were compared in human tumor cell lines of various histologic origins.

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References

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