Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct;18(4):257-9.
doi: 10.1016/j.jsps.2010.07.009. Epub 2010 Aug 3.

Tocilizumab: A new anti-rheumatic drug

Affiliations

Tocilizumab: A new anti-rheumatic drug

Hisham S Abou-Auda et al. Saudi Pharm J. 2010 Oct.
No abstract available

Keywords: Tocilizumab.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Blockade of IL-6 signals by anti-IL-6 receptor antibody (MRA, Tocilizumab). h, human; IL, interleukin; sIL-6R, soluble interleukin-6 receptor.
Figure 2
Figure 2
Feedback regulation in IL-6 signaling by SOCS. IL, interleukin; IL-6R, interleukin-6 receptor; JAK, Janus activated kinase; SOCS, suppressors of cytokine signaling; STAT, signal transducer and activator of transcription.

References

    1. Bongartz T. Tocilizumab for rheumatoid and juvenile idiopathic arthritis. Lancet. 2008;371 - PubMed
    1. European Medicines Agency (EMEA), 2009. Evaluation of Medicines for Human Use [Assessment Report for RoActemra], Doc. Ref.: EMEA/26276/2009, Procedure No. EMEA/H/C/000955.
    1. Gabay C. Interleukin-6 and chronic inflammation. Arthritis Research & Therapy. 2006;8(Suppl. 2):S3. - PMC - PubMed
    1. Haghighi A., Safari A. Tocilizumab may be a potential addition to our weapons against neuro-Behçet’s disease. Medical Hypothesis. 2008;71:156–157. - PubMed
    1. Kato A., Matsuo S., Takai Hirotake., Uchiyama Y., Mihara M., Suzuki M. Early effects of Tocilizumab on bone and bone marrow lesions in a collagen-induced arthritis monkey model. Experimental and Molecular Pathology. 2008;84:262–270. - PubMed

LinkOut - more resources