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. 2011 Apr;19(2):65-74.
doi: 10.1016/j.jsps.2011.01.007. Epub 2011 Jan 18.

Phytochemical and biological studies of Adiantum capillus-veneris L

Zedan Z Ibraheim  1 , Amany S Ahmed, Yaser G Gouda
Affiliations

Phytochemical and biological studies of Adiantum capillus-veneris L

Zedan Z Ibraheim et al. Saudi Pharm J. 2011 Apr.

Abstract

Chromatographic fractionation of the alcoholic extract of the dried fronds of Adiantum capillus-veneris L. (Adiantaceae) yielded seven compounds: four triterpenoidal compounds belonging to adiantane and filicane groups were isolated from the hexane fraction and identified as isoadiantone (1); isoadiantol-B (2); 3-methoxy-4-hydroxyfilicane (3) and 3,4-dihydroxyfilicane (4) and three flavonoids were isolated from the ethyl acetate fraction and identified as: quercetin (5), quercetin-3-O-glucoside (6) and quercetin-3-O-rutinoside (rutin) (7). The identification of the isolated compounds has been established through their physical, chemical and spectroscopic methods including IR, (1)H NMR, (13)C NMR, HSQC, HMBC, NOESY and MS. Biological studies of the total alcoholic extract, hexane fraction and some of the isolated compounds showed an anti-inflammatory activity while the hypoglycemic study of the total alcoholic extract showed a significant activity.

Keywords: Adiantane; Adiantum capillus-veneris L.; Anti-inflammatory; Filicane triterpenoids; Flavonoids; Hypoglycemic.

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Figures

Figure 1
Figure 1
Structures of the isolated triterpenoids.
Figure 2
Figure 2
Some HMBC correlation (→) of compounds 3 and 4 and NOESY correlation (formula image) of compound 4.
Figure 3
Figure 3
Some possible fragmentation pattern of compound 3.
Figure 4
Figure 4
Structures of the isolated flavonoids.
See this image and copyright information in PMC

References

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