[Changes in the functional and biochemical characteristics of the thrombocytes in the side effects of nonsteroidal anti-inflammatory preparations]

Abstract

Differences in the character of platelet response to aggregation inducers and inhibitors was revealed in atopy and pseudoallergy, with aspirin-sensitive asthma being chosen as its model. In atopy, activation of platelets and cAMP decrease in them under the action of ADP are observed as is an increase of TxB2 formation. In aspirin-sensitive asthma, inhibition of aggregation is observed; platelets become refractory to the action of ADP, with the decrease but not increase of cAMP level accompanying it after the action of the aggregation inducer. Changes in the formation of PGF2 alpha and TxB2 are observed simultaneously. In some patients with intolerance to non-steroid anti-inflammatory drugs, it is possible to find the same type of platelet reactions as in atopy. It allows one to suggest an IgE-dependent mechanism of drug allergy development.