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Review
. 2013 Nov;23(11):643-7.
doi: 10.1097/FPC.0b013e3283656bc1.

PharmGKB summary: tamoxifen pathway, pharmacokinetics

Daniel J Klein  1 , Caroline F Thorn, Zeruesenay Desta, David A Flockhart, Russ B Altman, Teri E Klein
Affiliations
Review

PharmGKB summary: tamoxifen pathway, pharmacokinetics

Daniel J Klein et al. Pharmacogenet Genomics. 2013 Nov.
No abstract available

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Figures

Fig. 1
Fig. 1
Graphic representation of the candidate genes involved in the pharmacokinetics of tamoxifen. A fully interactive version of this pathway is available online at PharmGKB at http://www.pharmgkb.org/pathway/PA145011119.
See this image and copyright information in PMC

References

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    1. Desta Z, Ward BA, Soukhova NV, Flockhart DA. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004;310:1062–1075. - PubMed
    1. Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998;90:1371–1388. - PubMed
    1. Goetz MP, Rae JM, Suman VJ, Safgren SL, Ames MM, Visscher DW, et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol. 2005;23:9312–9318. - PubMed
    1. Moyer AM, Suman VJ, Weinshilboum RM, Avula R, Black JL, Safgren SL, et al. SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen. Pharmacogenomics. 2011;12:1535–1543. - PMC - PubMed

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