Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Sep;43(5):386-401.
doi: 10.1007/s10519-013-9604-z. Epub 2013 Aug 21.

Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults

David B Chorlian  1 , Madhavi Rangaswamy, Niklas Manz, Jen-Chyong Wang, Danielle Dick, Laura Almasy, Lance Bauer, Kathleen Bucholz, Tatiana Foroud, Victor Hesselbrock, Sun J Kang, John Kramer, Sam Kuperman, John Nurnberger Jr, John Rice, Marc Schuckit, Jay Tischfield, Howard J Edenberg, Alison Goate, Laura Bierut, Bernice Porjesz
Affiliations

Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults

David B Chorlian et al. Behav Genet. 2013 Sep.

Abstract

Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence. The subjects were 2,938 adolescents and young adults ages 12-25. Results showed that the CHRM2 gene variants and ERO risk factors had hazards which varied considerably with age. The bulk of the significant age-specific associations occurred in those whose age of onset was under 16. These associations were concentrated in those subjects who at some time took an illicit drug. These results are consistent with studies which associate greater rates of alcohol dependence among those who begin drinking at an early age. The age specificity of the genetic and neurophysiological factors is consistent with recent studies of adolescent brain development, which locate an interval of heightened vulnerability to substance use disorders in the early to mid teens.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Adermark L, Clarke RB, Soderpalm B, Ericson M. Ethanol-induced modulation of synaptic output from the dorsolateral striatum in rat is regulated by cholinergic interneurons. Neurochem Int. 2011;58(6):693–9. - PubMed
    1. Agrawal A, Sartor CE, Lynskey MT, Grant JD, Pergadia ML, Grucza R, Bucholz KK, Nelson EC, Madden PA, Martin NG, Heath AC. Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms. Alcohol Clin Exp Res. 2009;33(12):2047–56. - PMC - PubMed
    1. Alfonso-Loeches S, Guerri C. Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. Crit Rev Clin Lab Sci. 2011;48(1):19–47. - PubMed
    1. Astle W, Balding DJ. 2009 Population Structure and Cryptic Relatedness in Genetic Association Studies http://arxiv.org/pdf/1010.4681.
    1. Baker JH, Maes HH, Larsson H, Lichtenstein P, Kendler KS. Sex differences and developmental stability in genetic and environmental influences on psychoactive substance consumption from early adolescence to young adulthood. Psychol Med. 2011;41(9):1907–16. - PMC - PubMed

Publication types

Substances