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. 2013 Sep;22(9):1620-7.
doi: 10.1158/1055-9965.EPI-13-0334. Epub 2013 Aug 20.

A pooled analysis of alcohol consumption and risk of multiple myeloma in the international multiple myeloma consortium

Gabriella Andreotti  1 , Brenda Birmann, Anneclaire J De Roos, John Spinelli, Wendy Cozen, Nicola J Camp, Kirsten Moysich, Brian Chiu, Emily Steplowski, Joseph Krzystan, Paolo Boffetta, Véronique Benhaim-Luzon, Paul Brennan, Silvia de Sanjosé, Laura Costas, Adele Seniori Costantini, Lucia Miligi, Pierluigi Cocco, Nikolaus Becker, Lenka Foretová, Marc Maynadié, Alexandra Nieters, Anthony Staines, Guido Tricot, Kevin Milliken, Dennis Weisenburger, Tongzhang Zheng, Dalsu Baris, Mark P Purdue
Affiliations

A pooled analysis of alcohol consumption and risk of multiple myeloma in the international multiple myeloma consortium

Gabriella Andreotti et al. Cancer Epidemiol Biomarkers Prev. 2013 Sep.

Abstract

Background: Recent findings suggest that alcohol consumption may reduce risk of multiple myeloma.

Methods: To better understand this relationship, we conducted an analysis of six case-control studies participating in the International Multiple Myeloma Consortium (1,567 cases, 7,296 controls). Summary ORs and 95% confidence intervals (CI) relating different measures of alcohol consumption and multiple myeloma risk were computed by unconditional logistic regression with adjustment for age, race, and study center.

Results: Cases were significantly less likely than controls to report ever drinking alcohol (men: OR = 0.72; 95% CI, 0.59-0.89; women: OR = 0.81; 95% CI, 0.68-0.95). The inverse association with multiple myeloma was stronger when comparing current to never drinkers (men: OR = 0.57; 95% CI, 0.45-0.72; women: OR = 0.55; 95% CI, 0.45-0.68), but null among former drinkers. We did not observe an exposure-response relationship with increasing alcohol frequency, duration, or cumulative lifetime consumption. Additional adjustment for body mass index, education, or smoking did not affect our results; and the patterns of association were similar for each type of alcohol beverage examined.

Conclusions: Our study is, to our knowledge, the largest of its kind to date, and our findings suggest that alcohol consumption may be associated with reduced risk of multiple myeloma.

Impact: Prospective studies, especially those conducted as pooled analyses with large sample sizes, are needed to confirm our findings and further explore whether alcohol consumption provides true biologic protection against this rare, highly fatal malignancy.

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Figures

Figure 1
Figure 1
a. Study-specific risks of multiple myeloma for ever versus never drinking alcohol among males. P-heterogeneity=0.61. b. Study-specific risks of multiple myeloma for ever versus never drinking alcohol among females. P-heterogeneity=0.40.
Figure 1
Figure 1
a. Study-specific risks of multiple myeloma for ever versus never drinking alcohol among males. P-heterogeneity=0.61. b. Study-specific risks of multiple myeloma for ever versus never drinking alcohol among females. P-heterogeneity=0.40.
See this image and copyright information in PMC

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