Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Aug;7(4):262-6.
doi: 10.4162/nrp.2013.7.4.262. Epub 2013 Aug 7.

Laxative effect of peanut sprout extract

Ji Yeon Seo  1 , Seong Soon Kim, Hyo Jung Kim, Kwang-Hyeon Liu, Hak-Yong Lee, Jong-Sang Kim
Affiliations

Laxative effect of peanut sprout extract

Ji Yeon Seo et al. Nutr Res Pract. 2013 Aug.

Abstract

Certain phenolic compounds are known to exhibit laxative properties. Seed sprouts, such as those of peanut, are known to promote de novo biosynthesis of phenolic compounds. This study was conducted to examine the potential laxative properties of 80% (v/v) ethanolic extract of peanut sprout (PSE), which contains a high concentration of phenolic compounds such as resveratrol. For this, SD rats were orally administered PSE while a control group was incubated with saline. Laxative effects were examined in both groups of rats. Constipation induced by loperamide in SD rats was improved by administration of PSE. Constipated rats showed increased intestinal movement of BaSO4 upon administration of PSE compared to the control, and the groups administered 100 or 1,000 mg PSE/kg bw were not significantly different in transit time of the indicator. However, colon length was not statistically different among the experimental groups, although it was longer in the group incubated with 1 g PSE/kg bw compared to other groups. Further, there was no significant difference in stool number among the experimental groups. Taken together, these findings show that PSE has a laxative effect in a rat model of loperamide-induced constipation.

Keywords: Peanut sprout; constipation; laxative effect.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Effects of peanut sprout extracts on changes in fecal number in loperamide-induced constipation model. Data are the means ± SD (n = 9). Bars with different letters from the control are significantly different (P < 0.05).
Fig. 2
Fig. 2
Effects of peanut sprout extracts on changes in fecal weight in loperamide-induced constipation model. Data are the means ± SD (n = 9). Bars with different letters from the control are significantly different (P < 0.05).
Fig. 3
Fig. 3
Effects of peanut sprout extracts on changes in fecal water content in loperamide-induced constipation model. Data are the means ± SD (n = 9). Bars with different letters from the control are significantly different (P < 0.05).
Fig. 4
Fig. 4
Effects of peanut sprout extracts on changes in intestinal length in loperamide-induced constipation model. Data are the means ± SD (n = 9).
See this image and copyright information in PMC

References

    1. Tabbers MM, Boluyt N, Berger MY, Benninga MA. Clinical practice: diagnosis and treatment of functional constipation. Eur J Pediatr. 2011;170:955–963. - PubMed
    1. Loening-Baucke V. Chronic constipation in children. Gastroenterology. 1993;105:1557–1564. - PubMed
    1. Mugie SM, Benninga MA, Di Lorenzo C. Epidemiology of constipation in children and adults: a systematic review. Best Pract Res Clin Gastroenterol. 2011;25:3–18. - PubMed
    1. Mostafa SM, Bhandari S, Ritchie G, Gratton N, Wenstone R. Constipation and its implications in the critically ill patient. Br J Anaesth. 2003;91:815–819. - PubMed
    1. Wu Z, Song L, Huang D. Food grade fungal stress on germinating peanut seeds induced phytoalexins and enhanced polyphenolic antioxidants. J Agric Food Chem. 2011;59:5993–6003. - PubMed