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. 2013 Aug;7(4):267-72.
doi: 10.4162/nrp.2013.7.4.267. Epub 2013 Aug 7.

Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets

Masayuki Yamasaki  1 , Tetsuro Ogawa, Li Wang, Takuya Katsube, Yukikazu Yamasaki, Xufeng Sun, Kuninori Shiwaku
Affiliations

Anti-obesity effects of hot water extract from Wasabi (Wasabia japonica Matsum.) leaves in mice fed high-fat diets

Masayuki Yamasaki et al. Nutr Res Pract. 2013 Aug.

Abstract

The anti-obesity effects of a hot water extract from wasabi (Wasabia japonica Matsum.) leaves (WLE), without its specific pungent constituents, such as allyl-isothiocyanate, were investigated in high fat-diet induced mice. C57J/BL mice were fed a high-fat diet (control group) or a high-fat diet supplemented with 5% WLE (WLE group). Physical parameters and blood profiles were determined. Gene expression associated with lipid metabolism in liver and white adipose tissue were analyzed. After 120 days of feeding, significantly lower body weight gain, liver weight and epididymal white adipose tissue weight was observed in the WLE group compared to the control group. In liver gene expression within the WLE group, PPARα was significantly enhanced and SREBP-1c was significantly suppressed. Subsequent downstream genes controlled by these regulators were significantly suppressed. In epididymal white adipose tissue of the WLE group, expression of leptin, PPARγ, and C/EBPα were significantly suppressed and adiponectin was significantly enhanced. Acox, related to fatty acid oxidization in adipocytes, was also enhanced. Our results demonstrate that the WLE dietary supplement induces mild suppression of obesity in a high-fat diet induced mice, possibly due to suppression of lipid accumulation in liver and white adipose tissue.

Keywords: Wasabia/Eutrema japonica Matsum.; hepatic gene expression; hepatic steatosis; obesity; white adipose tissue.

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Figures

Fig 1
Fig 1
Effects of WLE on body weight changes in mice. Each point represents mean ± SD (n = 10). Asterisks indicate significant difference between the WLE and control groups (P < 0.05).
Fig 2
Fig 2
Histological staining of liver sections and fat droplet areas of the control and WLE groups after feeding for 164 days
See this image and copyright information in PMC

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