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. 2013 Sep 6;15(17):4556-9.
doi: 10.1021/ol402110e. Epub 2013 Aug 21.

First total synthesis of hunanamycin A

Rahul D Shingare  1 , R Velayudham, Jalindar R Gawade, D Srinivasa Reddy
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First total synthesis of hunanamycin A

Rahul D Shingare et al. Org Lett. .

Abstract

The first total synthesis of hunanamycin A, an antibiotic natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core from a marine-derived Bacillus hunanensis, is disclosed. The present effort provides access to sufficient amounts of scarce hunanamycin A for further biological evaluation and confirmation of the assigned absolute configuration. In addition, four new analogues of the natural product are reported.

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