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. 2013 Aug 23;62(33):666.

Investigational drug available directly from CDC for the treatment of infections with free-living amebae

Centers for Disease Control and Prevention (CDC)

Investigational drug available directly from CDC for the treatment of infections with free-living amebae

Centers for Disease Control and Prevention (CDC). MMWR Morb Mortal Wkly Rep. .

Abstract

Infections caused by free-living amebae (FLA) are severe and life-threatening. These infections include primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri and granulomatous amebic encephalitis caused by Balamuthia mandrillaris and Acanthamoeba species. Although several drugs have in vitro activity against FLA, mortality from these infections remains>90% despite treatment with combinations of drugs.

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References

    1. Schuster FL, Guglielmo BJ, Visvesvara GS. In-vitro activity of miltefosine and voriconazole on clinical isolates of free-living amebas: Balamuthia mandrillaris, Acanthamoeba spp., and Naegleria fowleri. J Eukaryot Microbiol. 2006;53:121–6. - PubMed
    1. Cope JR, Roy SL, Yoder JS, Beach MJ. Improved treatment of granulomatous amebic encephalitis and other infections caused by Balamuthia mandrillaris and Acanthamoeba species [Poster]. Presented at Council of State and Territorial Epidemiologists’ Annual Conference; Pasadena, CA. June 9–13, 2013; Available at http://www.cste2.org/confpresentations/uploadedfiles/cste%202013%20milte....

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