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Review
. 2013 Aug 19;14(8):17111-21.
doi: 10.3390/ijms140817111.

NF90 in posttranscriptional gene regulation and microRNA biogenesis

Kiyoshi Masuda  1 , Yuki Kuwano, Kensei Nishida, Kazuhito Rokutan, Issei Imoto
Affiliations
Review

NF90 in posttranscriptional gene regulation and microRNA biogenesis

Kiyoshi Masuda et al. Int J Mol Sci. .

Abstract

Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis.

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Figures

Figure 1
Figure 1
NF90 structure. Diagram of NF90 and NF110 mRNA isoforms. Location of each exon is indicated by Arabic numbers. The translation start site in exon 2 is indicated by START. The translation stop sites in exon 18 and exon 21 are indicated by STOP. Polyadenylation sites are indicated by PAS.
See this image and copyright information in PMC

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