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. 2013 Aug 21;11(8):3068-76.
doi: 10.3390/md11083068.

Cytotoxic anthranilic acid derivatives from deep sea sediment-derived fungus Penicillium paneum SD-44

Chun-Shun Li  1 , Xiao-Ming Li, Shu-Shan Gao, Yan-Hua Lu, Bin-Gui Wang
Affiliations

Cytotoxic anthranilic acid derivatives from deep sea sediment-derived fungus Penicillium paneum SD-44

Chun-Shun Li et al. Mar Drugs. .

Abstract

Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.

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Figures

Figure 1
Figure 1
Structures of the isolated compounds 1–6.
Figure 2
Figure 2
Key HMBC (arrows) and 1H–1H COSY (bold lines) correlations of compounds 1, 3, and 5.
See this image and copyright information in PMC

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References

    1. Rateb M.E., Ebel R. Secondary metabolites of fungi from marine habitats. Nat. Prod. Rep. 2011;28:290–344. doi: 10.1039/c0np00061b. - DOI - PubMed
    1. Blunt J.W., Copp B.R., Munro M.H.G., Northcote P.T., Prinsep M.R. Marine natural products. Nat. Prod. Rep. 2011;28:196–268. doi: 10.1039/c005001f. - DOI - PubMed
    1. Blunt J.W., Copp B.R., Munro M.H.G., Northcote P.T., Prinsep M.R. Marine natural products. Nat. Prod. Rep. 2010;27:165–237. doi: 10.1039/b906091j. - DOI - PubMed
    1. Blunt J.W., Copp B.R., Hu W.P., Munro M.H.G., Northcote P.T., Prinsep M.R. Marine natural products. Nat. Prod. Rep. 2009;26:170–244. doi: 10.1039/b805113p. - DOI - PubMed
    1. Liu D., Li X.M., Meng L., Li C.S., Gao S.S., Shang Z., Proksch P., Huang C.G., Wang B.G. Nigerapyrones A–H, α-pyrone derivatives from the marine mangrove-derived endophytic fungus Aspergillus niger MA-132. J. Nat. Prod. 2011;74:1787–1791. doi: 10.1021/np200381u. - DOI - PubMed

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