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. 2013 Aug 21;11(8):3068-76.
doi: 10.3390/md11083068.

Cytotoxic anthranilic acid derivatives from deep sea sediment-derived fungus Penicillium paneum SD-44

Chun-Shun Li  1 , Xiao-Ming Li, Shu-Shan Gao, Yan-Hua Lu, Bin-Gui Wang
Affiliations

Cytotoxic anthranilic acid derivatives from deep sea sediment-derived fungus Penicillium paneum SD-44

Chun-Shun Li et al. Mar Drugs. .

Abstract

Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.

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Figures

Figure 1
Figure 1
Structures of the isolated compounds 1–6.
Figure 2
Figure 2
Key HMBC (arrows) and 1H–1H COSY (bold lines) correlations of compounds 1, 3, and 5.
See this image and copyright information in PMC

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