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Editorial
. 2013 Sep 1;12(17):2711-2.
doi: 10.4161/cc.26054. Epub 2013 Aug 19.

Hypothalamic inflammation and GnRH in aging development

Yizhe Tang  1 , Dongsheng Cai
Affiliations
Editorial

Hypothalamic inflammation and GnRH in aging development

Yizhe Tang et al. Cell Cycle. .
No abstract available

Keywords: GnRH; IKKβ; NFκB; aging; brain; hypothalamus; immunity; inflammation; metabolic syndrome.

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Figures

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Figure 1. Hypothalamic control of systemic aging. Age increase-associated environmental insults activate proinflammatory IKKβ/NFκB in hypothalamic microglia, and this inflammatory event further employs cytokines-directed autocrine and paracrine crosstalks among different types of neural cells to subsequently induce neuronal IKKβ/NFκB activation and inflammatory changes. Such hypothalamic inflammation eventually causes various defects in regulatory functions and neurogenesis of the hypothalamus, and impairment of GnRH production represents a significant basis. Ultimately, hypothalamic control of whole-body physiology is collectively compromised, contributing profoundly to the development of systemic aging.
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