Skinflammation and drug toxicity--a delicate balance
- PMID: 23966298
- DOI: 10.1126/scitranslmed.3006993
Skinflammation and drug toxicity--a delicate balance
Abstract
Loss of epidermal growth factor receptor function in epidermal keratinocytes triggers a disfiguring acneiform rash through the coordinate activation of innate and adaptive immune defense mechanisms (Mascia et al. and Lichtenberger et al., this issue).
Comment on
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Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy.Sci Transl Med. 2013 Aug 21;5(199):199ra110. doi: 10.1126/scitranslmed.3005773. Sci Transl Med. 2013. PMID: 23966299 Free PMC article. Clinical Trial.
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Epidermal EGFR controls cutaneous host defense and prevents inflammation.Sci Transl Med. 2013 Aug 21;5(199):199ra111. doi: 10.1126/scitranslmed.3005886. Sci Transl Med. 2013. PMID: 23966300
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