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Case Reports
. 2013 Aug 9:6:665-9.
doi: 10.2147/IJGM.S47397. eCollection 2013.

Warfarin-induced calciphylaxis: a case report and review of literature

Chadi Saifan  1 , Marc Saad, Elie El-Charabaty, Suzanne El-Sayegh
Affiliations
Case Reports

Warfarin-induced calciphylaxis: a case report and review of literature

Chadi Saifan et al. Int J Gen Med. .

Abstract

Calciphylaxis is a challenging complication of end-stage renal disease, with an unknown underlying mechanism. Several risk factors have been identified, such as hyperphosphatemia, hypercalcemia, hyperparathyroidism, low serum albumin levels, and history of warfarin therapy. This article presents a case of calciphylaxis provoked by reintroduction of warfarin therapy, introducing the possibility of direct induction.

Keywords: ESRD; calciphylaxis; skin necrosis; warfarin.

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Figures

Figure 1
Figure 1
Skin biopsy showing calcium deposition in small arterioles.
Figure 2
Figure 2
Calcified artery media in the pancreas.
Figure 3
Figure 3
Calcified artery media in the kidneys.
Figure 4
Figure 4
Day 10: thigh bullae and ulcerated skin.
Figure 5
Figure 5
Day 14: necrotic and eschar lesion.
Figure 6
Figure 6
Day 17: worsening necrotic lesion on extremities, flanks and lower abdomen.
Figure 7
Figure 7
Progressively worsening lesions on bilateral thigh.
Figure 8
Figure 8
Diffuse skin necrotic eschar.
See this image and copyright information in PMC

References

    1. Hafiji J, Deegan P, Brais R, Norris P. Warfarin-induced calciphylaxis successfully treated with sodium thiosulphate. Australas J Dermatol. 2013;54:133–135. - PubMed
    1. Hayashi M, Takamatsu I, Kanno Y, et al. Japanese Calciphylaxis Study Group A case-control study of calciphylaxis in Japanese end-stage renal disease patients. Nephrol Dial Transplant. 2012;27:1580–1584. - PubMed
    1. Brandenburg VM, Kramann R, Specht P, Ketteler M. Calciphylaxis in CKD and beyond. Nephrol Dial Transplant. 2012;27:1314–1318. - PubMed
    1. Jean G, Terrat JC, Vanel T, et al. [Calciphylaxis in dialysis patients: to recognize and treat it as soon as possible.] La calciphylaxie chez le patient dialysé : la reconnaître pour la traiter aussitôt que possible. Nephrol Ther. 2010;6:499–504. French. - PubMed
    1. Chacon G, Nguyen T, Khan A, Sinha A, Maddirala S. Warfarin-induced skin necrosis mimicking calciphylaxis: a case report and review of the literature. J Drugs Dermatol. 2010;9:859–863. - PubMed

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