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. 2013 Aug 14:3:210.
doi: 10.3389/fonc.2013.00210. eCollection 2013.

Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma

Gary E Mason  1 , Lele Aung, Sarah Gall, Paul A Meyers, Robert Butler, Sarah Krüg, Mimi Kim, John H Healey, Richard Gorlick
Affiliations

Quality of life following amputation or limb preservation in patients with lower extremity bone sarcoma

Gary E Mason et al. Front Oncol. .

Abstract

Purpose: Although functional differences have been described between patients with lower extremity bone sarcoma with amputation and limb-preservation surgery, differences have not clearly been shown between the two groups related to quality of life. The purpose of the study was to determine if there is a difference in overall quality of life in lower extremity bone sarcoma survivors related to whether they had an amputation or a limb-preservation procedure while identifying psychological differences for further evaluation. The main hypothesis was that sparing a person's limb, as opposed to amputating it, would result in a better quality of life.

Patients and methods: Eighty-two long-term survivors of lower extremity bone sarcoma were studied to make a comparison of the overall quality of life, pain assessment, and psychological evaluations in limb preservation and amputation patients. Forty-eight patients with limb preservation and thirty-four patients with amputations were enrolled in the study. Validated psychometric measures including the Quality of Life Questionnaire (QLQ), the Minnesota Multiphasic Personality Inventory, and visual analog scales were utilized.

Results: The overall quality of life of patients with limb preservation was significantly higher than patients with amputation (p-value < 0.01). Significant differences were noted in the categories of material well-being, job satisfiers, and occupational relations.

Conclusion: The overall quality of life of patients with limb-preservation appears to be better than for those patients with amputation based on the QLQ in patients surviving lower extremity bone sarcoma. Further analysis needs to verify the results and focus on the categories that significantly affect the overall quality of life.

Keywords: amputation; limb salvage; orthopedic outcomes; quality of life; sarcoma.

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References

    1. Williard WC, Collin C, Casper ES. The changing role of amputation for soft tissue sarcoma of the extremity in adults. Surg Gynecol Obstet (1992) 175:389–96 - PubMed
    1. Rosen G, Murphy ML, Huvos AG, Gutierrez M, Marcove RC. Chemotherapy, en bloc resection, and prosthetic bone replacement in the treatment of osteogenic sarcoma. Cancer (1976) 37:1–11 10.1002/1097-0142(197601)37:1<1::AID-CNCR2820370102>3.0.CO;2-3 - DOI - PubMed
    1. Eilber FR, Eckhardt J, Morton DL. Advance in the treatment of sarcomas of the extremity: current status of limb salvage surgery. Cancer (1984) 54:2695–701 10.1002/1097-0142(19841201)54:2+<2695::AID-CNCR2820541415>3.0.CO;2-O - DOI - PubMed
    1. Eilber FR, Morton DL, Eckardt J, Grant T, Weisenburger T. Limb salvage for skeletal and soft tissue sarcomas. Cancer (1984) 53:2579–84 10.1002/1097-0142(19840615)53:12<2579::AID-CNCR2820531202>3.0.CO;2-V - DOI - PubMed
    1. Brennan MF, Casper ES, Harrison LB, Shiu MH, Gaynor J, Hajdu SI. The role of multimodality therapy in soft-tissue sarcoma. Ann Surg (1991) 214:328–37 10.1097/00000658-199109000-00015 - DOI - PMC - PubMed

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