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. 2013 Sep 6;15(17):4600-3.
doi: 10.1021/ol4022113. Epub 2013 Aug 22.

Cu-catalyzed cross-dehydrogenative coupling reactions of (benzo)thiazoles with cyclic ethers

Zengyang Xie  1 , Yuping Cai, Hongwen Hu, Chen Lin, Juli Jiang, Zhaoxu Chen, Leyong Wang, Yi Pan
Affiliations

Cu-catalyzed cross-dehydrogenative coupling reactions of (benzo)thiazoles with cyclic ethers

Zengyang Xie et al. Org Lett. .

Abstract

Copper-catalyzed cross-dehydrogenative coupling (CDC) reactions of (benzo)thiazoles with cyclic ethers were developed under mild conditions. In particular, the formation of C-C bonds via the CDC reactions between non-benzo-fused azoles and ethers are reported for the first time. In addition, the acetals, known as the masked 2-thiazolecarboxaldehydes, could be successfully obtained by this CDC reaction. The preliminary mechanism and supportive DFT calculations are discussed as well.

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