Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2013 Jun;51(2):53-7.
doi: 10.1016/j.aat.2013.06.009. Epub 2013 Aug 1.

Different dosing regimens for propofol induction in obese patients

Fai Lam  1 , Chien-Chang Liao, Yi-Jui Lee, Weu Wang, Chien-Ju Kuo, Chao-Shun Lin
Affiliations
Randomized Controlled Trial

Different dosing regimens for propofol induction in obese patients

Fai Lam et al. Acta Anaesthesiol Taiwan. 2013 Jun.

Erratum in

Abstract

Objectives: The aim of the study is to investigate the efficacy of different dosages of single bolus propofol administered on the basis of total body weight or corrected body weight for the intravenous induction of anesthesia in obese patients undergoing bariatric surgery.

Materials and methods: Thirty-eight obese patients with a body mass index (BMI) of 30 kg/m(2) or greater were randomly divided into two groups. They received single-bolus propofol (2 mg/kg) for intravenous induction of anesthesia based on either total body weight (TBW; 20 patients) or corrected body weight 60% (CBW60; 18 patients). Patients' characteristics, biochemical data, monitored bispectral index (BIS) values, and hemodynamic parameters were compared between the two groups.

Results: The propofol dose was significantly lower in the CBW60 group than in the TBW group (189.5 ± 36.3 mg vs. 217.3 ± 39.1 mg, respectively; p = 0.03). The highest BIS value, representing potential awareness after intubation, was relatively higher in the CBW60 group, but this difference was not statistically significant (CBW60 group, 53.6 ± 11.1; TBW group, 48.6 ± 8.1; p = 0.22). Eighty-three percent of patients experienced hypotension during induction and at least 44% patients showed marked hypotension. There was no significant difference between the TBW and CBW60 groups in blood pressure after intubation.

Conclusion: When using single bolus propofol, the CBW60 group showed similar BIS values and hemodynamic effects as the TBW group during the intravenous induction of general anesthesia for obese patients.

Keywords: bispectral index; electroencephalography; obesity; propofol.

PubMed Disclaimer

Publication types