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Comment
. 2013 Oct;14(10):852-3.
doi: 10.1038/embor.2013.133. Epub 2013 Aug 23.

Ncking BCR-mediated PI3K activation

Jennifer L Cannons  1 , Fang Zhao, Pamela L Schwartzberg
Affiliations
Comment

Ncking BCR-mediated PI3K activation

Jennifer L Cannons et al. EMBO Rep. 2013 Oct.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Nck links the BCR to PI3K activation. Engagement of the BCR triggers the phosphorylation of the Igα and Igβ chains by SFK, leading to the recruitment and activation of Syk and the subsequent phosphorylation of SLP65, which recruits molecules important for downstream signalling. Among these, the Nck adaptor molecule links this complex to actin regulatory proteins, such as WASp. Batista and colleagues show that Nck also directly binds to the Igα chain to link it to BCAP, a critical regulator of PI3K pathways. BCAP, B-cell adaptor for PI3K; BCR, B-cell receptor; Nck, non-catalytic region of tyrosine kinase adaptor protein; PI3K, phosphoinositide 3-kinase; SFK, Src family kinase; SLP65, SH2-domain-containing leucocyte protein 65 kDa; WASp, Wiskott–Aldrich syndrome protein.
See this image and copyright information in PMC

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