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Review
. 2014 Feb;46(2):144-51.
doi: 10.1002/lsm.22170. Epub 2013 Aug 23.

Low-level laser (light) therapy (LLLT) for treatment of hair loss

Pinar Avci  1 , Gaurav K Gupta, Jason Clark, Norbert Wikonkal, Michael R Hamblin
Affiliations
Review

Low-level laser (light) therapy (LLLT) for treatment of hair loss

Pinar Avci et al. Lasers Surg Med. 2014 Feb.

Abstract

Objective: Alopecia is a common disorder affecting more than half of the population worldwide. Androgenetic alopecia, the most common type, affects 50% of males over the age of 40 and 75% of females over 65. Only two drugs have been approved so far (minoxidil and finasteride) and hair transplant is the other treatment alternative. This review surveys the evidence for low-level laser therapy (LLLT) applied to the scalp as a treatment for hair loss and discusses possible mechanisms of actions.

Methods and materials: Searches of PubMed and Google Scholar were carried out using keywords alopecia, hair loss, LLLT, photobiomodulation.

Results: Studies have shown that LLLT stimulated hair growth in mice subjected to chemotherapy-induced alopecia and also in alopecia areata. Controlled clinical trials demonstrated that LLLT stimulated hair growth in both men and women. Among various mechanisms, the main mechanism is hypothesized to be stimulation of epidermal stem cells in the hair follicle bulge and shifting the follicles into anagen phase.

Conclusion: LLLT for hair growth in both men and women appears to be both safe and effective. The optimum wavelength, coherence and dosimetric parameters remain to be determined.

Keywords: LLLT; alopecia; androgenetic alopecia; hair loss; low level laser (light).

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Figures

Fig. 1
Fig. 1
Stages of hair cycle. Anagen stage is the growth stage which may last 2–6 years. In cagaten stage, club hair transitions upwards towards the skin pore and the dermal papilla begins to separate from the follicle. This phase usually lasts from 1 to 2 weeks. In telogen stage, the dermal papilla fully separates from the follicle and it takes about 5–6 weeks. Lastly, the dermal papilla moves upward to meet hair follicle once again and the hair matrix begins to form new hair, which represents the return to anagen stage.
See this image and copyright information in PMC

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