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. 2013 Aug 21:4:105.
doi: 10.3389/fendo.2013.00105. eCollection 2013.

RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication

Yasuhiko Yamamoto  1 , Hiroshi Yamamoto
Affiliations

RAGE-Mediated Inflammation, Type 2 Diabetes, and Diabetic Vascular Complication

Yasuhiko Yamamoto et al. Front Endocrinol (Lausanne). .

Abstract

Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promoting inflammatory reactions. The receptor for advanced glycation end-products (RAGE) is a member of PRRs and a proinflammatory molecular device that mediates danger signals to the body. The expression of RAGE is observed in adipocytes as well as immune cells, endothelial cells, and pancreatic β cells under certain conditions. It has been reported that RAGE is implicated in adipocyte hypertrophy and insulin resistance. RAGE-mediated regulation of adiposity and inflammation may attribute to type 2 diabetes and diabetic vascular complications.

Keywords: inflammation; obesity; pattern-recognition receptors; rage; toll-like receptors.

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Figures

Figure 1
Figure 1
RAGE is implicated in obesity, type 2 diabetes, and vascular diseases. PRRs, pattern-recognition receptors; RAGE, receptor for advanced glycation end-products; TLRs, toll-like receptors.
See this image and copyright information in PMC

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