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. 2013 Aug;22(3):212-9.

The Neurobiological Basis of Adolescent-onset Borderline Personality Disorder

Marianne Goodman  1 , Kathryn Mascitelli, Joseph Triebwasser
Affiliations

The Neurobiological Basis of Adolescent-onset Borderline Personality Disorder

Marianne Goodman et al. J Can Acad Child Adolesc Psychiatry. 2013 Aug.

Abstract
in English, French

Objective: Over the past two decades, neurobiological studies in adult onset borderline personality disorder have made important strides, but inquiry into adolescent-onset BPD is still in its infancy and our understanding of the neurobiology of adolescent BPD remains highly tentative.

Methods: This paper highlights recent findings in genetics, neuroendocrinology and neuroimaging for adult and adolescent-onset BPD.

Results: Neurobiological studies of adolescent-onset BPD to date have focused mainly on volumetric studies of various brain regions and measurements of HPA axis components, with comparatively few publications on brain functioning.

Conclusion: Such information is essential to developing more effective screening, treatment and preventive strategies.

Objectif: Au cours des vingt dernières années, les études neurobiologiques du trouble de la personnalité limite (TPL) apparu à l’âge adulte ont fait de grands progrès, mais l’étude de l’apparition de la TPL à l’adolescence en est encore à ses premiers pas, et notre compréhension de la neurobiologie du TPL adolescent demeure très provisoire.

Méthodes: Cet article présente les résultats récents de la génétique, de la neuroendocrinologie et de la neuroimagerie pour le TPL apparu à l’âge adulte et à l’adolescence.

Résultats: Les études neurobiologiques du TPL apparu à l’adolescence ont porté jusqu’ici surtout sur les études volumétriques des diverses régions cérébrales et sur des mesures des composantes de l’axe hypothalamo-hypophyso-surrénalien, et n’ont donné lieu comparativement qu’à peu de publications sur le fonctionnement du cerveau. Conclusion: Cette information est essentielle au développement de stratégies efficaces de dépistage, de traitement et de prévention.

Keywords: Borderline Personality Disorder; adolescent; neurobiology; neuroimaging.

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