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Clinical Trial
. 1978;6(1):4-10.
doi: 10.1177/030006057800600102.

Oxypertine in combination with imipramine: a controlled trial

M Sim, E B Gordon, C G Nicol
Clinical Trial

Oxypertine in combination with imipramine: a controlled trial

M Sim et al. J Int Med Res. 1978.

Abstract

A method for the controlled assessment of two agents for possible interaction in the treatment of endogenous depression is described. This consisted of dose-ranging the supplementary agent (oxypertine 30 mg and 60 mg daily or matching placebo) during Week 2 to Week 6 having established all patients on a therapeutic dose of imipramine during Week 1. The reported enhancement of imipramine by oxypertine was not confirmed.

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