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Comment
. 2013 Aug 22;39(2):199-201.
doi: 10.1016/j.immuni.2013.08.014.

4C-ing the Igh Landscape

Laura Nicolás  1 , Jayanta Chaudhuri
Affiliations
Comment

4C-ing the Igh Landscape

Laura Nicolás et al. Immunity. .

Abstract

The assembly of antigen receptors in developing B lymphocytes is determined by the spatio-temporal organization of the immunoglobulin heavy chain locus (Igh). In this issue of Immunity, Medvedovic et al. (2013) provide a comprehensive dynamic view of the Igh locus architecture.

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Figures

Fig 1
Fig 1. Dynamic architecture of the IgH locus
Top.Schematic representation of the Ighlocus showing Variable (V), Diversity (D), Joining gene segments (J), Constant regions (C) and the regulatory elements 3′RR, Eμ, IGCR1 and PAIR elements. The CTCF-binding sequence (3′CBE) in the 3′RR region are shown. Bottom.Interactions in the absence or presence of Pax5. Green, grey, pink and blue arrows represent local interactions between the pointed sequences and the corresponding viewpoints. Broken green arrows represent dynamic long-range interactions. Distal VH genes interact mainly with CTCF-binding sites in IGCR1 and 3′CBE. Black triangles indicate the relative position of the 16 viewpoints that were employed for 4C-seq analyses.
See this image and copyright information in PMC

Comment on

References

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